Which factor is most likely to contribute to Ketoacidosis?

The factor that most likely contributes to ketoacidosis is the metabolization of fatty acids. In the absence of sufficient insulin, the body cannot utilize glucose effectively for energy. As a result, it begins to break down fatty acids as an alternative source of energy. This process leads to the production of ketones, which are acidic byproducts. When ketones accumulate in the bloodstream, they can lower blood pH and lead to ketoacidosis, particularly in individuals with uncontrolled diabetes.

Metabolizing fatty acids is a key physiological response when glucose is not available, and in the context of diabetes, it can trigger the dangerous state known as diabetic ketoacidosis (DKA). Conditions that promote this process, such as low insulin levels, are critical to understanding the pathophysiology of ketoacidosis. In contrast, other factors mentioned, such as insulin injection and high carbohydrate intake, typically help to regulate blood glucose levels and prevent such a breakdown of fatty acids, while a low fat diet would not contribute to the excess availability of fatty acids for metabolism.